False negative screening tests in phenylketonuria.
نویسندگان
چکیده
منابع مشابه
False Positive and False Negative Results in Urine Drug Screening Tests: Tampering Methods and Specimen Integrity Tests
Urine drug screening can detect cases of drug abuse, promote workplace safety, and monitor drugtherapy compliance. Compliance testing is necessary for patients taking controlled drugs. To order and interpret these tests, it is required to know of testing modalities, kinetic of drugs, and different causes of false-positive and false-negative results. Standard immunoassay testing is fast, cheap, ...
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متن کاملScreening for Phenylketonuria
Newborn screening for phenylketonuria (PKU) started with Robert Guthrie (1916–1995) who developed the bacterial inhibition test for the semiquantitative analysis of phenylalanine, which was the first test suitable for high throughput analysis. In addition, he introduced the ‘Guthrie filter card’ as a transport medium for dried blood which is still used today. Realizing the potential of his appr...
متن کاملNeonatal screening for phenylketonuria.
The case histories are reported of three patients with phenylketonuria (PKU) in whom the initial Guthrie screening for PKU was falsely negative. Possible explanations for this problem are reviewed, as well as the limited cost-effectiveness of general re-testing. Guidelines are suggested to im prove the sensitivity of PKU screening procedures for newborns.
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1971
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.46.245.124